Product Recovery and Purification

What we offer:

  • Expertise in development, scale-up and demonstration of product recovery and purification processes
  • A broad range of processing equipment for aqueous and solvent based applications
  • Flexibility in setting up dedicated process lines

Equipment overview:

The equipment overview below gives an idea of the variety of modular operation units we have available to perform your purification and product recovery processes. However, this list is not complete. If you are looking for specific equipment not listed below, do not hesitate to contact us.

High speed disc stack centrifuges (60 L/h to 3 m³/h):

  • Solid-Liquid separators (ca. 7000 RCF)
    • GEA: max. 60 L/h
    • Alfa Laval: max. 100 L/h
    • GEA: max. 500 L/h
    • Alfa Laval: max. 3 m³/h
  • Liquid-liquid or 3 phase separator (ca. 12000 RCF)
    • GEA: ATEX; ca. 1 m³/h

Decanter centrifuges (ca. 3000 RCF):

  • Alfa Laval: max. 500 L/h
  • Alfa Laval: max. 3 m³/h

Basket centrifuges for crystal separation: 

  • Pilot unit: 10 kg; 1850 rpm
  • ATEX pilot unit: 40 kg; 1700 rpm
  • Heinkel inverting filter centrifuge: 52 L; 1940 rpm

Cross flow membrane filtration (MF, UF, NF): 

  • Flat sheet pilot unit: testing of several membranes in parallel; max 2 m²
  • Spiral wound filtration (MF, UF, NF)
    • NF, RO Bench scale unit: ca. 0.23 m²
    • MF, UF unit: Single 3.8-inch membrane unit; max. 5.7 m²
    • MF, UF unit: Twelve 3.8-inch membranes; max. 70 m²
    • MF, UF unit: Six 6.3-inch membranes; max. 6 bar; max 150 m²
    • NF unit: Nine 8-inch membranes; max. 40 bar, max. 150 m²
  • Ceramic filtration
    • MF, UF Bench scale unit: max. 0.032 m²
    • MF, UF Single unit 1 or 3 membranes: 0.2 or 0.6 m²
    • MF, UF pilot unit: 55 membranes x 0.2 m² = 11 m²
    • MF, UF pilot unit: 110 membranes x 0.2 m² = 22 m²
    • MF industrial unit (0.5 µm): 288 m²
  • Hollow fiber filtration (MF, UF)
    • MF, UF Bench scale unit: 0.037 m²
    • MF, UF pilot unit: 10 and 500 kDA; max. 12.4 m²
    • MF, UF pilot unit: 150 kDa; max. 50 m²

Dead end filtration 

  • Chamber filter presses
    • Bench scale unit: cake volume 1.44 L; max. 822 cm² filtration area
    • Pilot unit: cake volume 68 L; max. 2.5 m² filtration area
    • Pilot unit: cake volume 120 L; max. 6.5 m² filtration area
    • Large pilot unit: cake volume 352 L; max. 35 m² filtration area ; cake squeezing
    • Large pilot unit ATEX: cake vol. 100 L; max. 7.7 m² filtration area; cake squeezing
  • Filter dryer 1900 L for solvent extraction, (pre-coat) filtration and solids drying
  • Plate and frame units with cardboard filters
  • Candle filters
  • Rotary vacuum drum filter RVDF (3 m²)
  • See ‘Basket centrifuges for crystal separation’

Ion exchange and adsorption 

Columns for ion exchange, adsorption chromatography or activated carbon treatment

  • Bench scale glass columns: 300 mL
  • Glass columns: 3 x 5 L resin; max. 1 bar
  • Fiberglass columns: 3 x 30 L resin; max. 16 bar
  • Fiberglass columns: 4 x 300 L; 4 x 1 m³; 1 x 1.3 m³; 4 x 1.9 m³; 2 x 3 m³ resin; max. 10 bar

Crystallization 

  • Benchtop reactors 500 mL and 2 L for cooling- and/or evaporation crystallization
  • Various reactors from 50 L to 5.4 m³ (several ATEX) for cooling- and/or evaporation crystallization
  • Continuous cooling crystallization unit 50 L
  • Crystallization line up to 1000 t/y equipped with crystallizer 4 m³, inverted basket centrifuge, rotary louvre dryer

Evaporation 

  • Wiped film evaporators, 2 kg/h and 150 kg/h
  • Spinning cone evaporator, up to 50 kg/h
  • Falling film three-effect evaporator, 5 t/h
  • Batch evaporation reactors for both water and solvent based distillation

Extraction ATEX

  • Filter dryer  1900 L for solvent extraction, (pre-coat) filtration and solids drying
  • Karr column (6 L/h) for counter current liquid-liquid extraction
  • Glass lined reactors, 500 L, 1000 L and 5400 L for solid-liquid and liquid-liquid extractions
  • Phase separation with disc stack centrifuge; max. 2 m³/h

Chromatography

  • GRACE bench scale preparative chromatography unit
  • Columns up to 500 L for batch chromatography

Drying 

  • Louvre crystal dryer ca. 4 kg/h water evaporation
  • Vacuum tray dryer, 300 L filling volume
  • Filter dryer, 1900 L (ATEX)
  • Drying oven, 2000 L
  • Spray dryer, 1 kg/h water evaporation
  • Spray dryer, 15 kg/h water evaporation
  • Lyophilizer, 8 kg water per drying cycle
  • Access to external freeze- and spray drying facilities

Various 

  • Multipurpose temperature-controlled process tanks up to 8000 L
  • Storage and process buffer tanks up to 50 m³
  • Solvent tanks ATEX 4 x 30 m³
  • High pressure homogenizer, cell disruptor (10 L/h; max. 1200 bar)
  • High pressure homogenizer, cell disruptor (850 L/h; max. 1200 bar)
  • Access to a wide range of rental equipment

DSP1 4x3 DSP2 4x3 Product Recovery and Purification @ Bio Base Europe Pilot Plant